Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease.

doi:10.1136/jmg.31.3.197

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Article

Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease.

Journal of medical genetics - 1 Mar 1994

Liddell M, Williams J, Bayer A, Kaiser F, Owen M

Abstract excerpt

The Apo E genotype of 86 patients with Alzheimer's disease (AD) and 77 age matched controls was determined by digestion of Apo E PCR products with the restriction enzyme CfoI. The frequency of the e4 allele was significantly increased in the patient group (0.33) as compared with controls (0.12). This effect was seen in patients with a family history and in sporadic cases. The odds ratio in homozygotes for the e4...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Analysis of Variance
Apolipoprotein E4
Apolipoproteins E
Case-Control Studies
Chi-Square Distribution
Chromosomes, Human, Pair 19
Deoxyribonucleases, Type II Site-Specific

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Frequency

Humans

Male

Odds Ratio

Polymerase Chain Reaction

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 8014966
DOI: 10.1136/jmg.31.3.197
PMCID: PMC1049741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8014966-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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