The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G --> A) in a 5'-CGT-3' sequence context.

doi:10.1021/bi970541+

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Article

The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G --> A) in a 5'-CGT-3' sequence context.

Biochemistry - 19 Aug 1997

Shukla R, Liu T, Geacintov N E, Loechler E L

Abstract excerpt

Mutations induced by the (+)-anti diol epoxide of benzo[a]pyrene [(+)-anti-B[a]PDE] were described previously in the supF gene of the Escherichia coli plasmid pUB3 [Rodriguez et al.(1993) Biochemistry, 32, 1759]. (+)-anti-B[a]PDE induced a complex pattern of mutations, including insertions, delet...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Chromatography, High Pressure Liquid
DNA Adducts
Genes, Suppressor
Mutagenesis
Mutagens
Mutation
Plasmids
RNA, Transfer

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