Article
Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma.
American journal of respiratory cell and molecular biology - 1 Jul 1994
Lane S J, Arm J P, Staynov D Z, Lee T H
Abstract excerpt
Corticosteroid-resistant (CR) asthma is not caused by altered bioavailability of the administered drug, altered ligand-binding characteristics, or altered nuclear translocation of the activated human glucocorticoid receptor (hGR) complex. We have tested the hypothesis that CR asthma results from a consistent polymorphism in the functionally diverse hGR cDNA using the sensitive screening technique of polymerase...
Topics
- Adult
- Asthma
- Autoradiography
- Base Sequence
- DNA Mutational Analysis
- DNA, Complementary
- Drug Resistance
- Electrophoresis, Polyacrylamide Gel
- Glucocorticoids
- Humans
- Male