Article
The DNA and steroid binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Jan 1995
Soufi M, Kaiser U, Schneider A, Beato M, Westphal H M
Abstract excerpt
The aim of this study was to investigate whether mutations in the glucocorticoid receptor could account for the increasing unresponsiveness of patients with chronic lymphatic leukemia (CLL) to combination chemotherapy. The receptor was tested immunocytochemically, in steroid binding assays, and b...
Topics
- Animals
- Antineoplastic Combined Chemotherapy Protocols
- Base Sequence
- Drug Resistance
- Glucocorticoids
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukocytes, Mononuclear
- Lymphoma
- Mice
- Molecular Sequence Data
- Mutation
- Receptors, Glucocorticoid
- Sequence Analysis, DNA