Reversion of altered phenotype in primary cultured rat hepatocytes after intrahepatic and intrasplenic transplantation.

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Article

Reversion of altered phenotype in primary cultured rat hepatocytes after intrahepatic and intrasplenic transplantation.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 1994

Nishikawa Y, Ohta T, Ogawa K, Nagase S

Abstract excerpt

BACKGROUND: The phenotype of isolated rat hepatocytes changes during in vitro cultivation, but it is not clear whether this process turns back when the cells are returned to an in vivo milieu. Glutathione S-transferase placental form (GST-P), which is not expressed in hepatocytes in vivo, is induced within a few days of cultivation, whereas cytochrome P-450 constitutionally expressed in hepatocytes in vivo...

Topics

Animals
Biomarkers
Cells, Cultured
Cytochrome P-450 Enzyme System
Enzyme Induction
Female
Glutathione Transferase
Immunohistochemistry
Isoenzymes
Liver
Liver Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Phenotype

Placenta

Pregnancy

Rats

Rats, Inbred F344

Serum Albumin

Source

Open in PubMed

Identifiers

PMID: 8015296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8015296-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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