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Article

The Genetic Variation of Porcine Reproductive and Respiratory Syndrome Virus Replicase Protein nsp2 Modulates Viral Virulence and Persistence.

Journal of virology - 30 Mar 2023

Kong Can, Li Dan, Hu Yanxin, Gao Peng, Zhang Yongning, Zhou Lei, Ge Xinna, Guo Xin, Han Jun, Yang Hanchun

Abstract excerpt

Fast evolution in the field of the replicase nsp2 represents a most prominent feature of porcine reproductive and respiratory syndrome virus (PRRSV). Here, we determined its biological significance in viral pathogenesis by constructing interlineage chimeric mutants between the Chinese highly pathogenic PRRSV (HP-PRRSV) strain JXwn06 (lineage 8) and the low-virulent NADC30-like strain CHsx1401 (lineage 1)....

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Identifiers

PMID: 36916907
DOI: 10.1128/jvi.01689-22
PMCID: PMC10062138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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