Article
sir2 mutants of Kluyveromyces lactis are hypersensitive to DNA-targeting drugs.
Molecular and cellular biology - 1 Jul 1994
Chen X J, Clark-Walker G D
Abstract excerpt
A Kluyveromyces lactis mutant, hypersensitive to the DNA-targeting drugs ethidium bromide (EtBr), berenil, and HOE15030, can be complemented by a wild-type gene with homology to SIR2 of Saccharomyces cerevisiae (ScSIR2). The deduced amino acid sequence of the K. lactis Sir2 protein has 53% identi...
Topics
- Amino Acid Sequence
- Cloning, Molecular
- Crosses, Genetic
- DNA, Fungal
- DNA, Mitochondrial
- DNA-Binding Proteins
- Ethidium
- Fungal Proteins
- Genes, Fungal
- Genotype
- Histone Deacetylases
- Kluyveromyces
- Molecular Sequence Data
- Mutagenesis
- Restriction Mapping
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid
- Silent Information Regulator Proteins, Saccharomyces cerevisiae