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Article

sir2 mutants of Kluyveromyces lactis are hypersensitive to DNA-targeting drugs.

Molecular and cellular biology - 1 Jul 1994

Chen X J, Clark-Walker G D

Abstract excerpt

A Kluyveromyces lactis mutant, hypersensitive to the DNA-targeting drugs ethidium bromide (EtBr), berenil, and HOE15030, can be complemented by a wild-type gene with homology to SIR2 of Saccharomyces cerevisiae (ScSIR2). The deduced amino acid sequence of the K. lactis Sir2 protein has 53% identity with ScSir2 protein but is 108 residues longer. K. lactis sir2 mutants show decreased mating efficiency, deficiency...

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Identifiers

PMID: 8007956
DOI: 10.1128/mcb.14.7.4501-4508.1994
PMCID: PMC358822

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