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Article

Meiotic segregation analysis of RB1 alleles in retinoblastoma pedigrees by use of single-sperm typing.

American journal of human genetics - 1 Jan 2000

Girardet A, McPeek M S, Leeflang E P, Munier F, Arnheim N, Claustres M, Pellestor F

Abstract excerpt

In hereditary retinoblastoma, different epidemiological studies have indicated a preferential paternal transmission of mutant retinoblastoma alleles to offspring, suggesting the occurrence of a meiotic drive. To investigate this mechanism, we analyzed sperm samples from six individuals from five unrelated families affected with hereditary retinoblastoma. Single-sperm typing techniques were performed for each...

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Identifiers

PMID: 10631148
DOI: 10.1086/302715
PMCID: PMC1288323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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