Article
Putative non-Mendelian transmission of retinoblastoma in males: a phenotypic segregation analysis of 150 pedigrees.
Human genetics - 1 Nov 1994
Munier F L, Arabien L, Flodman P, Spence M A, Pescia G, Rutz H P, Murphree A L
Abstract excerpt
In a previous genotypic study of eight families, we described paternal segregation distortion favoring the transmission of mutant alleles at the retinoblastoma gene locus (RB1). In the current study, we reviewed all published retinoblastoma pedigrees with defined ascertainment (n = 150), to deter...
Topics
- Female
- Genes, Retinoblastoma
- Genetic Linkage
- Heterozygote
- Humans
- Likelihood Functions
- Male
- Pedigree
- Phenotype
- Retinoblastoma
- Retrospective Studies
- Sex Factors
- Sex Ratio