Bile acids do not form adducts when incubated with DNA in vitro.

doi:10.1093/carcin/15.12.2945

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Article

Bile acids do not form adducts when incubated with DNA in vitro.

Carcinogenesis - 1 Dec 1994

Scates D K, Spigelman A D, Venitt S

Abstract excerpt

Bile acids have been implicated in the aetiology of colon cancer. We have previously found, using 32P-postlabelling, that bile from control patients and from patients with familial adenomatous polyposis (FAP) produces DNA adducts when incubated with salmon sperm DNA in vitro. In the present study we have incubated the common primary and secondary, conjugated and unconjugated bile acids with salmon sperm DNA in...

Topics

Adenomatous Polyposis Coli
Animals
Bile Acids and Salts
Biotransformation
Colonic Neoplasms
DNA Adducts
Genetic Predisposition to Disease
Humans
Microsomes, Liver
Rats

Source

Open in PubMed

Identifiers

PMID: 8001260
DOI: 10.1093/carcin/15.12.2945

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8001260-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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