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Global methylation, oxidative stress and relative telomere length in biliary atresia patients

31 May 2016

Abstract excerpt

Alu and LINE-1 elements are retrotransposons with a ubiquitous presence in the human genome that can cause genomic instability, specifically relating to telomere length. Genotoxic agents may induce methylation of retrotransposons, in addition to oxidative DNA damage in the form of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Methylation of retrotransposons induced by these agents may contribute to biliary atresia (BA)...

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PMID: 27243754
DOI: 10.1038/srep26969

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