Article
A dominant mutation in the bacteriophage lambda S gene causes premature lysis and an absolute defective plating phenotype.
Molecular microbiology - 1 Aug 1994
Johnson-Boaz R, Chang C Y, Young R
Abstract excerpt
The S and R genes of the bacteriophage lambda are required for lysis of the host. R encodes 'endolysin', a soluble transglycosylase which accumulates in the cytoplasm during late protein synthesis. S encodes a 'holin', a small membrane protein which, at a precisely scheduled time, terminates the vegetative cycle by forming a lethal lesion in the membrane through which gpR gains access to the peptidoglycan. A...
Topics
- Alleles
- Amino Acid Sequence
- Bacteriolysis
- Bacteriophage lambda
- Base Sequence
- Endopeptidases
- Escherichia coli
- Genes, Dominant
- Genes, Viral
- Molecular Sequence Data
- Mutation