Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells.

doi:10.1002/jlb.56.6.732

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells.

Journal of leukocyte biology - 1 Dec 1994

Ulvestad E, Williams K, Bjerkvig R, Tiekotter K, Antel J, Matre R

Abstract excerpt

Resting microglia comprise up to 13% of the cells in human central nervous system (CNS) white matter. Their large number and dendritic morphology make them ideally suited to survey the CNS for noxious stimuli. Upon activation microglia gradually lose dendritic processes and transform into typical phagocytic macrophages. Microglia have been implicated as the main antigen presenting cell within the CNS, and appear...

Topics

Adult
Antibodies, Monoclonal
CD4-Positive T-Lymphocytes
Cells, Cultured
Dendritic Cells
Erythrocytes
Histocytochemistry
Humans
Immunoglobulin G
Interferon-gamma
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophage Activation

Macrophages

Microglia

Multiple Sclerosis

Phagocytosis

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7996050
DOI: 10.1002/jlb.56.6.732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7996050-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells.PMID 7996050Read ↗

MicrogliaSemantic proximity Read ↗

Microglial Phenotypes and Functions in Multiple Sclerosis.Semantic proximity Read ↗

Beyond Activation: Characterizing Microglial Functional Phenotypes.Semantic proximity Read ↗

Microglial cell origin and phenotypes in health and disease.Semantic proximity Read ↗

Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia.Semantic proximity Read ↗

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains.Semantic proximity Read ↗

Immortalized human microglial cell line: phenotypic expression.Semantic proximity Read ↗

Microglia phenotype diversity.Semantic proximity Read ↗

Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets.Semantic proximity Read ↗

Microglial phenotype and adaptation.Semantic proximity Read ↗

Phenotypic differences between human monocytes/macrophages and microglial cells studied in situ and in vitro.Semantic proximity Read ↗

Microglia as therapeutic target in central nervous system disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.