Evidence of genetic heterogeneity in Romano-Ward long QT syndrome. Analysis of 23 families.

doi:10.1161/01.cir.90.6.2635

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Article

Evidence of genetic heterogeneity in Romano-Ward long QT syndrome. Analysis of 23 families.

Circulation - 1 Dec 1994

Towbin J A, Li H, Taggart R T, Lehmann M H, Schwartz P J, Satler C A, Ayyagari R, Robinson J L, Moss A, Hejtmancik J F

Abstract excerpt

BACKGROUND: The Romano-Ward long-QT Syndrome (LQTS) is an autosomal dominant inherited trait characterized by prolonged QT interval on ECG, life-threatening arrhythmias, syncope, and sudden death in affected individuals. A gene responsible for this disorder has been shown to be linked to the Harv...

Topics

Base Sequence
Chromosome Mapping
Genes, ras
Genetic Linkage
Genetic Variation
Humans
Long QT Syndrome
Molecular Sequence Data
Oligonucleotide Probes
Pedigree
Tyrosine 3-Monooxygenase

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