Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoplastic left heart syndrome links to chromosomes 10q and 6q and is genetically related to bicuspid aortic valve.

Journal of the American College of Cardiology - 24 Mar 2009

Hinton Robert B, Martin Lisa J, Rame-Gowda Smitha, Tabangin Meredith E, Cripe Linda H, Benson D Woodrow

Abstract excerpt

OBJECTIVES: This study was designed to identify disease loci for hypoplastic left heart syndrome (HLHS) and evaluate the genetic relationship between HLHS and bicuspid aortic valve (BAV). BACKGROUND: Previously, we identified that HLHS and BAV exhibit complex inheritance, and both HLHS and BAV kindreds are enriched for BAV. However, the genetic basis of HLHS and its relationship to BAV remains unclear. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Valve
Share to Chromosomes, Human, Pair 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 6

Share to Echocardiography

Share to Genetic Heterogeneity

Share to Inheritance Patterns

Share to Lod Score

Share to Statistics, Nonparametric

Source

Open in PubMed Open full text

Identifiers

PMID: 19298921
DOI: 10.1016/j.jacc.2008.12.023
PMCID: PMC2703749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoplastic left heart syndrome links to chromosomes 10q and 6q and is genetically related to bicuspid aortic valve.PMID 19298921Read ↗

Hypoplastic left heart syndrome is heritable.Semantic proximity Read ↗

CELSR1 Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome.Semantic proximity Read ↗

Human Genetics of Hypoplastic Left Heart Syndrome.Semantic proximity Read ↗

Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations.Semantic proximity Read ↗

Linkage analysis of left ventricular outflow tract malformations (aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome).Semantic proximity Read ↗

The complex genetics of hypoplastic left heart syndrome.Semantic proximity Read ↗

Whole exome sequencing for familial bicuspid aortic valve identifies putative variants.Semantic proximity Read ↗

Risk factors for aortic valve disease in bicuspid aortic valve: A family‐based studySemantic proximity Read ↗

Risk of congenital heart disease in relatives of probands with conotruncal cardiac defects: An evaluation of 1,620 familiesSemantic proximity Read ↗

Inheritance analysis of congenital left ventricular outflow tract obstruction malformations: Segregation, multiplex relative risk, and heritabilitySemantic proximity Read ↗

Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study.Semantic proximity Read ↗

Prevalence of congenital cardiovascular malformations among relatives of infants with hypoplastic left heart, coarctation of the aorta, and d‐transposition of the great arteriesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.