Article
Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene.
Science (New York, N.Y.) - 3 May 1991
Keating M, Atkinson D, Dunn C, Timothy K, Vincent G M, Leppert M
Abstract excerpt
Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes...
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