Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene.

doi:10.1126/science.1673802

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Article

Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene.

Science (New York, N.Y.) - 3 May 1991

Keating M, Atkinson D, Dunn C, Timothy K, Vincent G M, Leppert M

Abstract excerpt

Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes...

Topics

Chromosome Mapping
Chromosomes, Human, Pair 11
Electrocardiography
Genes, ras
Humans
Lod Score
Long QT Syndrome
Mutation
Pedigree
Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1673802
DOI: 10.1126/science.1673802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1673802-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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