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Article

Genetic heterogeneity of heart-hand syndromes.

Circulation - 1 Mar 1995

Basson C T, Solomon S D, Weissman B, MacRae C A, Poznanski A K, Prieto F, Ruiz de la Fuente S, Pease W E, Levin S E, Holmes L B

Abstract excerpt

BACKGROUND: Heart-hand syndromes compose a class of combined congenital cardiac and limb deformities. The proto-typical heart-hand disorder is Holt-Oram syndrome, which is characterized by cardiac septation defects and radial ray limb deformity. We have recently mapped the Holt-Oram syndrome gene defect to the long arm of human chromosome 12 in two families. The role of this disease locus in the pathogenesis of...

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Identifiers

PMID: 7867169
DOI: 10.1161/01.cir.91.5.1326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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