Article
Locus heterogeneity of autosomal dominant long QT syndrome.
The Journal of clinical investigation - 1 Aug 1993
Curran M, Atkinson D, Timothy K, Vincent G M, Moss A J, Leppert M, Keating M
Abstract excerpt
Autosomal dominant long QT syndrome (LQT) is an inherited disorder that causes syncope and sudden death from cardiac arrhythmias. In genetic linkage studies of seven unrelated families we mapped a gene for LQT to the short arm of chromosome 11 (11p15.5), near the Harvey ras-1 gene (H ras-1). To d...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Female
- Genes, Dominant
- Genes, ras
- Genetic Linkage
- Genetic Markers
- Haplotypes
- Humans
- Lod Score
- Long QT Syndrome
- Male
- Pedigree
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length