Article
Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia.
Blood - 15 Dec 1994
Nakao S, Takamatsu H, Chuhjo T, Ueda M, Shiobara S, Matsuda T, Kaneshige T, Mizoguchi H
Abstract excerpt
Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated wi...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Anemia, Aplastic
- Autoimmune Diseases
- Cyclosporine
- Female
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Humans
- Incidence