Article
Absence of insulin receptor gene mutations in three insulin-resistant women with the polycystic ovary syndrome.
Metabolism: clinical and experimental - 1 Dec 1994
Sorbara L R, Tang Z, Cama A, Xia J, Schenker E, Kohanski R A, Poretsky L, Koller E, Taylor S I, Dunaif A
Abstract excerpt
Women with polycystic ovary syndrome (PCOS) are markedly insulin-resistant, but the molecular mechanisms of these changes and their relationship to the hyperandrogenic state remain to be clarified. Mutations have recently been identified in the insulin receptor gene of patients with extreme forms of insulin resistance associated with hyperandrogenism (eg, type A insulin resistance), and these mutations account...
Topics
- Adult
- Base Sequence
- Cells, Cultured
- Electrophoresis, Polyacrylamide Gel
- Female
- Fibroblasts
- Humans
- Insulin Resistance
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization