Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains.

Genome research - 1 Apr 1997

Oeltjen J C, Malley T M, Muzny D M, Miller W, Gibbs R A, Belmont J W

Abstract excerpt

Large-scale genomic DNA sequencing of orthologous and paralogous loci in different species should contribute to a basic understanding of the evolution of both the protein-coding regions and noncoding regulatory elements. We compared 93 kb of human sequence to 89 kb of mouse sequence in the Bruton's tyrosine kinase (BTK) region. In addition to showing the conservation of both position and orientation of the five...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Molecular Sequence Data

Share to Promoter Regions, Genetic

Share to Recombinant Proteins

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 9110171
DOI: 10.1101/gr.7.4.315

Genes

BTK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains.PMID 9110171Read ↗

Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase ( Btk ) loci.Semantic proximity Read ↗

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.Semantic proximity Read ↗

A novel isoform of the B cell tyrosine kinase BTK protects breast cancer cells from apoptosisSemantic proximity Read ↗

Bruton's tyrosine kinase is a key regulator in B-cell development.Semantic proximity Read ↗

Somatic cell mapping of the SKI proto-oncogene to bovine syntenic group U25 (BTA 27)Semantic proximity Read ↗

Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan.Semantic proximity Read ↗

The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective.Semantic proximity Read ↗

Genomic organization and structure of Bruton agammaglobulinemia tyrosine kinase: localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia.Semantic proximity Read ↗

Identification and functional validation of a 5' upstream regulatory sequence in the human tyrosinase gene homologous to the locus control region of the mouse tyrosinase gene.Semantic proximity Read ↗

Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14.Semantic proximity Read ↗

Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I.Semantic proximity Read ↗

Transcription of the blk Gene in Human B Lymphocytes Is Controlled by Two PromotersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.