Article
Assessment of liver metabolic function. Clinical implications.
Clinical pharmacokinetics - 1 Sept 1994
Brockmöller J, Roots I
Abstract excerpt
Inter- and intraindividual variability in pharmacokinetics of most drugs is largely determined by variable liver function as described by parameters of hepatic blood flow and metabolic capacity. These parameters may be altered as a result of disease affecting the liver, genetic differences in metabolising enzymes, and various types of drug interactions, including enzyme induction, enzyme inhibition or...
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