Minimal sizes of cases with a susceptible genotype and minimal odds ratios among susceptible individuals in case-control studies.

Abstract excerpt

OBJECTIVE: Disease risk elevation due to an environmental factor only for individuals with a susceptible genotype is a typical example of gene-environment interaction. In order to identify risk factors interacting with susceptible genotypes in case-control studies, presumptions on minimal size of cases with the susceptible genotype (S (min)) and odds ratio (OR) among the susceptible individuals (OR(susceptible))...

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