Article
[Molecular genetics of mitochondria and diabetes].
Nihon rinsho. Japanese journal of clinical medicine - 1 Oct 1994
Kagawa Y
Abstract excerpt
The molecular genetics of mitochondria relevant to NIDDM is described, because the mutations in mitochondrial DNA cause diabetes. The non-Mendelian genetics, including maternal inheritance, heteroplasmy, stochastic segregation are characteristic of mitochondrial gene. Since aging causes rapid loss of mitochondrial function, which results in the retardation of insulin secretion via ATP-sensitive K-channel. This...
Topics
- Cellular Senescence
- DNA, Mitochondrial
- Diabetes Mellitus, Type 2
- Humans
- Mitochondria
- Mutation
- Telomere