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Article

[The molecular mechanism of insulin biosynthesis and mutant insulin gene syndrome].

Nihon rinsho. Japanese journal of clinical medicine - 1 Oct 1994

Nishi M, Nanjo K

Abstract excerpt

The biosynthetic process of insulin in pancreatic beta cells consists of many steps including transcription of insulin gene to mRNA, translation of mRNA to preproinsulin, production of proinsulin by cleavage of signal peptide, and conversion of proinsulin to insulin and C-peptide. This process also includes intra-cellular trafficking (nucleus, cytoplasm, endoplasmic reticulum, Golgi apparatus, secretary granule,...

Topics

Animals
Humans
Insulin
Islets of Langerhans
Mutation
Proinsulin
Protein Biosynthesis
Transcription, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7983772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7983772-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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