Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA

1 Jan 1995

Abstract excerpt

We have assembled derivatives of Epstein-Barr Virus (EBV) that include 71 kbp of noncontiguous DNA sequences cloned into a prokaryotic F-factor plasmid. These mini-EBVs, when introduced into an EBV-containing lymphoblastoid cell, can be packaged by the endogenous helper virus. One such mini-EBV was found to have a single C residue deleted from its EBNA3a open reading frame. When packaged, this mini-EBV initiates...

Source

Identifiers

PMID: 7983714
DOI: 10.1128/jvi.69.1.231-238.1995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNAPMID 7983714Read ↗

Immortalization of human primary B lymphocytes in vitro with DNA.Semantic proximity Read ↗

Propagation and recovery of intact, infectious Epstein–Barr virus from prokaryotic to human cellsSemantic proximity Read ↗

The plasmid replicon of Epstein–Barr virus: Mechanistic insights into efficient, licensed, extrachromosomal replication in human cellsSemantic proximity Read ↗

Immortalization of human lymphocytes by Epstein-Barr virus.Semantic proximity Read ↗

A first-generation packaging cell line for Epstein–Barr virus-derived vectorsSemantic proximity Read ↗

B cells immortalized by a mini–Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cellsSemantic proximity Read ↗

Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus.Semantic proximity Read ↗

Genetic analysis of the role of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) in B cell transformationSemantic proximity Read ↗

The latent membrane protein 2 gene of Epstein-Barr virus is important for efficient B cell immortalization.Semantic proximity Read ↗

Development of a Novel Helper-Dependent Adenovirus-Epstein-Barr Virus Hybrid System for the Stable Transformation of Mammalian CellsSemantic proximity Read ↗

Steps Involved in Immortalization and Tumorigenesis in Human B-Lymphoblastoid Cell Lines Transformed by Epstein-Barr VirusSemantic proximity Read ↗

Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.