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Article

A first-generation packaging cell line for Epstein–Barr virus-derived vectors

27 Apr 1999

Abstract excerpt

On the basis of the B lymphotropic Epstein-Barr virus (EBV), we have constructed a virus-free packaging cell line that allows encapsidation of plasmids into herpesvirus particles. This cell line harbors an EBV mutant whose packaging signals have been deleted. The gene vectors, which can encompass very large, contiguous pieces of foreign DNA, carry all cis-acting elements involved in amplification and...

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Identifiers

PMID: 10220441
DOI: 10.1073/pnas.96.9.5188

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