Article
Direct measurement of in vivo flux differences between electrophoretic variants of G6PD from Drosophila melanogaster.
Genetics - 1 Nov 1992
Labate J, Eanes W F
Abstract excerpt
Demonstrating that naturally occurring enzyme polymorphisms significantly impact metabolic pathway flux is a fundamental step in examining the possible adaptive significance of such polymorphisms. In earlier studies of the glucose-6-phosphate dehydrogenase (G6PD) polymorphism in Drosophila melanogaster, we used two different methods, exploiting both genotype-dependent interactions with the 6Pgd locus, and...
Topics
- Animals
- Drosophila melanogaster
- Electrophoresis, Polyacrylamide Gel
- Genetic Variation
- Genotype
- Glucosephosphate Dehydrogenase
- Pentose Phosphate Pathway
- Polymorphism, Genetic