Article
Analysis of adenomatous polyposis coli gene in thyroid tumours.
British journal of cancer - 1 Dec 1994
Colletta G, Sciacchitano S, Palmirotta R, Ranieri A, Zanella E, Cama A, Mariani Costantini R, Battista P, Pontecorvi A
Abstract excerpt
Familial adenomatous polyposis (FAP) is known to be associated with neoplasia of various tissues, including thyroid carcinoma. Germline mutations of the tumour-suppressor gene APC, responsible for the predisposition to FAP, may therefore be involved in the pathogenesis of these tumours. In this report the structure of the APC gene has been investigated in 26 thyroid tumours, at different stages of...
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