Article
Evidence against involvement of APC mutation in papillary thyroid carcinoma.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1994
Curtis L, Wyllie A H, Shaw J J, Williams G T, Radulescu A, DeMicco C, Haugen D R, Varhaug J E, Lillehaug J R, Wynford-Thomas D
Abstract excerpt
Papillary thyroid carcinoma (PTC) is one of several tumours associated with familial adenomatous polyposis (FAP), an inherited tumour syndrome which appears to result from germ-line mutation of the APC tumour suppressor gene. Here we investigate the possibility that somatic mutation of APC might...
Topics
- Adolescent
- Adult
- Aged
- Base Sequence
- Carcinoma, Papillary
- DNA Mutational Analysis
- Female
- Gene Amplification
- Genes, APC
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Thyroid Neoplasms