Article
Evidence against involvement of APC mutation in papillary thyroid carcinoma.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1994
Curtis L, Wyllie A H, Shaw J J, Williams G T, Radulescu A, DeMicco C, Haugen D R, Varhaug J E, Lillehaug J R, Wynford-Thomas D
Abstract excerpt
Papillary thyroid carcinoma (PTC) is one of several tumours associated with familial adenomatous polyposis (FAP), an inherited tumour syndrome which appears to result from germ-line mutation of the APC tumour suppressor gene. Here we investigate the possibility that somatic mutation of APC might play a role in sporadic PTC. 16 cases of PTC together with matched normal tissue were examined by single-strand...
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