Mutations of the adenomatous polyposis coli gene in sporadic thyroid neoplasms.

doi:10.1210/jcem.79.5.7962323

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Article

Mutations of the adenomatous polyposis coli gene in sporadic thyroid neoplasms.

The Journal of clinical endocrinology and metabolism - 1 Nov 1994

Zeki K, Spambalg D, Sharifi N, Gonsky R, Fagin J A

Abstract excerpt

Several epidemiological studies have demonstrated an association between familial adenomatous polyposis coli (FAP) and thyroid neoplasms. Predisposition to FAP is conferred by mutations in the APC gene, located on chromosome 5q21. Somatic mutations of APC are also observed in about 60% of sporadi...

Topics

Adenoma
Base Sequence
DNA, Neoplasm
Gene Expression Regulation, Neoplastic
Genes, APC
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA, Messenger
Thyroid Gland
Thyroid Neoplasms

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