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Article

Seminiferous Cord Formation and Germ‐Cell Programming: Epigenetic Transgenerational Actions of Endocrine Disruptors

1 Dec 2005

Abstract excerpt

The molecular and cellular control of embryonic testis development was investigated through an analysis of the embryonic testis transcriptome to identify potential regulatory factors for male sex determination and testis morphogenesis. One critical factor identified is neurotropin 3 (NT3). At the onset of male sex determination, Sertoli cells initiate differentiation and express NT3 to act as a chemotactic factor...

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Identifiers

PMID: 16467254
DOI: 10.1196/annals.1336.004

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