Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm.

doi:10.1530/REP-09-0340

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Article

Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm.

Reproduction (Cambridge, England) - 1 Feb 2010

Stouder Christelle, Paoloni-Giacobino Ariane

Abstract excerpt

Endocrine-disrupting chemicals (EDCs), among which is the antiandrogen vinclozolin (VCZ), have been reported to affect the male reproductive system. In this study, VCZ was administered to pregnant mice at the time of embryo sex determination, and its possible effects on the differentially methylated domains (DMDs) of two paternally (H19 and Gtl2) and three maternally (Peg1, Snrpn, and Peg3) imprinted genes were...

Topics

Androgen Antagonists
Animals
CpG Islands
DNA Methylation
Endocrine Disruptors
Female
Genomic Imprinting
Genotype
Kruppel-Like Transcription Factors
Liver
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Muscle, Skeletal

Oxazoles

Phenotype

Pregnancy

Prenatal Exposure Delayed Effects

Proteins

Source

Open in PubMed

Identifiers

PMID: 19887539
DOI: 10.1530/REP-09-0340

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