Article
T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.
The Journal of experimental medicine - 1 Nov 1994
Tian J, Lehmann P V, Kaufman D L
Abstract excerpt
Limited regions of amino acid sequence similarity frequently occur between microbial antigens and host proteins. It has been widely anticipated that during infection such sequence similarities could induce cross-reactive T cell responses, thereby initiating T cell-mediated autoimmune disease. How...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Cross Reactions
- Diabetes Mellitus, Type 1
- Enterovirus
- Glutamate Decarboxylase
- Haplotypes
- Histocompatibility Antigens Class II
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Molecular Sequence Data
- T-Lymphocytes
- Viral Proteins