Article
Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Oct 1999
Klemetti P, Hyöty H, Roivainen M, Ilonen J, Savola K, Knip M, Akerblom H K, Vaarala O
Abstract excerpt
BACKGROUND: the role of enteroviruses has been implicated in the etiology of insulin-dependent diabetes mellitus (IDDM). A possible connection between glutamate decarboxylase (GAD) autoimmunity and enterovirus infections in IDDM has been suggested to be based on a homology region between GAD and the non-structural protein 2C of coxsackievirus B4 (CVB4). OBJECTIVES: the aims of the study were to measure the...
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