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Article

Selection of a gyrA Mutant of Mycobacterium tuberculosis Resistant to Fluoroquinolones during Treatment with Ofloxacin

1 Aug 1994

Abstract excerpt

A strain of Mycobacterium tuberculosis resistant to ofloxacin was selected in a patient with a long history of multidrug-resistant tuberculosis eventually treated by ofloxacin combined with other second-line drugs. A mutation in the gyrA gene was hypothesized to be the mechanism of acquired resistance to ofloxacin in this strain. Chromosomal DNA of strains MTB1, isolated before treatment and susceptible to...

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Identifiers

PMID: 7963747
DOI: 10.1093/infdis/170.2.479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Selection of a gyrA Mutant of Mycobacterium tuberculosis Resistant to Fluoroquinolones during Treatment with OfloxacinPMID 7963747Read ↗

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High Proportion of Fluoroquinolone-Resistant Mycobacterium tuberculosis Isolates with Novel Gyrase Polymorphisms and a <i>gyrA</i> Region Associated with Fluoroquinolone SusceptibilitySemantic proximity Read ↗

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