Article
Purified reconstituted inositol 1,4,5-trisphosphate receptors. Thiol reagents act directly on receptor protein.
The Journal of biological chemistry - 18 Nov 1994
Kaplin A I, Ferris C D, Voglmaier S M, Snyder S H
Abstract excerpt
Thimerosal, a sulfhydryl oxidizing reagent, has been shown to induce Ca2+ mobilization in several cell types and to increase the sensitivity of intracellular Ca2+ stores to inositol 1,4,5-trisphosphate (IP3). Using purified IP3 receptor (IP3R) protein reconstituted in vesicles, we demonstrate pronounced stimulation by thimerosal of its Ca2+ channel activity. Effects of thimerosal are dependent on the redox state...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosomes
- DNA, Circular
- DNA, Protozoan
- Gene Amplification
- Genes, Protozoan
- IMP Dehydrogenase
- Molecular Sequence Data
- Mycophenolic Acid