Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Purified reconstituted inositol 1,4,5-trisphosphate receptors. Thiol reagents act directly on receptor protein.

The Journal of biological chemistry - 18 Nov 1994

Kaplin A I, Ferris C D, Voglmaier S M, Snyder S H

Abstract excerpt

Thimerosal, a sulfhydryl oxidizing reagent, has been shown to induce Ca2+ mobilization in several cell types and to increase the sensitivity of intracellular Ca2+ stores to inositol 1,4,5-trisphosphate (IP3). Using purified IP3 receptor (IP3R) protein reconstituted in vesicles, we demonstrate pronounced stimulation by thimerosal of its Ca2+ channel activity. Effects of thimerosal are dependent on the redox state...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Chromosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Protozoan

Share to Gene Amplification

Share to Molecular Sequence Data

Share to Phenotype

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 7961860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Purified reconstituted inositol 1,4,5-trisphosphate receptors. Thiol reagents act directly on receptor protein.PMID 7961860Read ↗

Calcium-dependent conformational changes in inositol trisphosphate receptors.Semantic proximity Read ↗

[Inositol 1,4,5-trisphosphate receptor (IP3 receptor)].Semantic proximity Read ↗

Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel.Semantic proximity Read ↗

[Molecular and functional diversity of inositol triphosphate-induced Ca(2+) release].Semantic proximity Read ↗

The Ca2+-Sensing Receptor (CaR) Activates Phospholipases C, A2, and D in Bovine Parathyroid and CaR-Transfected, Human Embryonic Kidney (HEK293) CellsSemantic proximity Read ↗

IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.Semantic proximity Read ↗

Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract.Semantic proximity Read ↗

Mechanism of proteasomal degradation of inositol trisphosphate receptors in CHO-K1 cells.Semantic proximity Read ↗

Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.