Article
Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.
Genes & development - 1 Aug 1994
Hatakeyama M, Brill J A, Fink G R, Weinberg R A
Abstract excerpt
The retinoblastoma gene product (pRB) constrains cell proliferation by preventing cell-cycle progression from the G1 to S phase. Its growth-inhibitory effects appear to be reversed by hyperphosphorylation occurring during G1. This process is thought to involve G1 cyclins and cyclin-dependent kinases (cdks). Here we report that the cell cycle-dependent phosphorylation of mammalian pRB is faithfully reproduced when...
Topics
- CDC28 Protein Kinase, S cerevisiae
- Cyclins
- G1 Phase
- Genetic Complementation Test
- Humans
- Mating Factor
- Mutation
- Peptides
- Phosphorylation
- Recombinant Proteins
- Retinoblastoma Protein