Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toxoplasma gondii: Characterization of a Mutant Resistant to 6-Thioxanthine

1 Nov 1994

Abstract excerpt

6-Thioxanthine caused 50% inhibition of the growth of Toxoplasma gondii in human fibroblasts at a concentration of 5 micrograms/ml. A mutant induced by treatment with ethylnitrosourea (ThxR-1) was 20-fold more resistant than the wildtype. Wild-type parasites grown in Lesch-Nyhan fibroblasts efficiently incorporated hypoxanthine, guanine, and xanthine, but ThxR-1 incorporated each of these precursors less than 2%...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Toxoplasma gondii Research Studies

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 7957757
DOI: 10.1006/expr.1994.1099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toxoplasma gondii: Characterization of a Mutant Resistant to 6-ThioxanthinePMID 7957757Read ↗

Purine Salvage Pathways in the Apicomplexan Parasite Toxoplasma gondiiSemantic proximity Read ↗

Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit-and-run mutagenesis.Semantic proximity Read ↗

Toxoplasma gondii: Are Host Cell Adenosine Nucleotides a Direct Source for Purine Salvage?Semantic proximity Read ↗

Isolation of Developmentally Regulated Genes from Toxoplasma gondii by a Gene Trap with the Positive and Negative Selectable Marker Hypoxanthine-Xanthine-Guanine PhosphoribosyltransferaseSemantic proximity Read ↗

Amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases.Semantic proximity Read ↗

A novel mechanism of mycophenolic acid resistance in the protozoan parasite Tritrichomonas foetus.Semantic proximity Read ↗

Toxoplasma gondii: characterization of a mutant resistant to sulfonamides.Semantic proximity Read ↗

Secondary mutations correct fitness defects in Toxoplasma gondii with dinitroaniline resistance mutations.Semantic proximity Read ↗

Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii.Semantic proximity Read ↗

Toxoplasma gondii: susceptibility and development of resistance to anticoccidial drugs in vitro.Semantic proximity Read ↗

A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani.Semantic proximity Read ↗

A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.