Article
Induction of DNA strand breaks by ethylene oxide in human diploid fibroblasts.
Environmental and molecular mutagenesis - 1 Jan 1994
Nygren J, Cedervall B, Eriksson S, Dusinská M, Kolman A
Abstract excerpt
In vitro exposure of normal human diploid fibroblasts (strain VH-10) to ethylene oxide (EtO) induced DNA strand breaks in the dose range of 2.5-30 mMh of EtO. Alkaline DNA unwinding (ADU), neutral filter elution (NFE), pulsed field gel electrophoresis (PFGE), and the comet assay were used to measure DNA single (SSBs) and double strand breaks (DSBs). Different induction rates of SSBs and DSBs, depending on applied...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.