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Article

Lymphoproliferative disease in mice infected with murine gammaherpesvirus 68.

The American journal of pathology - 1 Oct 1994

Sunil-Chandra N P, Arno J, Fazakerley J, Nash A A

Abstract excerpt

Murine gammaherpesvirus is a natural pathogen of wild rodents. In the laboratory it establishes an infection of epithelial cells and persists in B lymphocytes in a latent form. Inbred mice chronically infected with the virus develop a lymphoproliferative disease (LPD) similar to that seen in patients infected with Epstein-Barr virus. The frequency of LPD over a period of 3 years was 9% of all infected animals,...

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PMID: 7943173
PMCID: PMC1887324

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