Article
Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1.
Yeast (Chichester, England) - 1 Apr 1994
Shirayama M, Matsui Y, Tanaka K, Toh-e A
Abstract excerpt
We have identified MSI2 as a gene of Saccharomyces cerevisiae which, when on a multicopy vector, suppresses the heat shock sensitivity caused by the loss of the IRA1 product, a negative regulator of the RAS protein. The multicopy MSI2 also suppresses the heat shock sensitivity of cells with the RAS2val19 mutation but not those with the bcy1 mutation, suggesting that the MSI2 protein may interfere with the...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Cycle
- Cold Temperature
- Fungal Proteins
- GTPase-Activating Proteins
- Genes, Fungal
- Genes, Suppressor
- Guanine Nucleotide Exchange Factors
- Metaphase
- Molecular Sequence Data