Article
Detection of oxidative mutagens in strains of Escherichia coli deficient in the OxyR or MutY functions: dependence on SOS mutagenesis.
Mutation research - 1 Nov 1995
Urios A, Herrera G, Blanco M
Abstract excerpt
The Escherichia coli strain IC3821, a delta oxyR derivative of WP2 uvrA trpE65, was more sensitive to mutagenicity promoted by t-butyl hydroperoxide and cumene hydroperoxide than the isogenic oxyR+ control. Mutagenicity of menadione, a redox cycling quinone, was clearly detected in the delta oxyR...
Topics
- Benzene Derivatives
- DNA Damage
- DNA Glycosylases
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Gene Deletion
- Mutagens
- Mutation
- N-Glycosyl Hydrolases
- Oxidation-Reduction
- Peroxides
- Repressor Proteins
- SOS Response, Genetics
- Transcription Factors
- tert-Butylhydroperoxide