Article
On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase.
Journal of molecular biology - 6 Dec 2002
Kulik Victor, Weyand Michael, Seidel Ralf, Niks Dimitri, Arac Demet, Dunn Michael F, Schlichting Ilme
Abstract excerpt
The catalytic activity and substrate channeling of the pyridoxal 5'-phosphate-dependent tryptophan synthase alpha(2)beta(2) complex is regulated by allosteric interactions that modulate the switching of the enzyme between open, low activity and closed, high activity states during the catalytic cycle. The highly conserved alphaThr183 residue is part of loop alphaL6 and is located next to the alpha-active site and...
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