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Article

PIG-A gene mutations in four Taiwanese patients with paroxysmal nocturnal haemoglobinuria following aplastic anaemia.

British journal of haematology - 1 May 1997

Lin L I, Liu C H, Chen Y C, Shen M C, Wang C H, Huang Y L, Lin J K

Abstract excerpt

Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired haemolytic disorder caused by deficient biosynthesis of the glycosyl phosphatidylinositol (GPI) anchor in haemopoietic stem cells. PIG-A, an X-linked gene that participates in the first step of GPI-anchor synthesis, is responsible for PNH....

Topics

Anemia, Aplastic
CD55 Antigens
CD57 Antigens
Clone Cells
Erythrocytes
Flow Cytometry
Frameshift Mutation
Gene Deletion
Glycosylphosphatidylinositols
Hemoglobinuria, Paroxysmal
Humans
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Thrombocytopenia

Source

Identifiers

PMID: 9163589
DOI: 10.1046/j.1365-2141.1997.442690.x

Genes

GPI
AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9163589-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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