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Article

Lap4, a vacuolar aminopeptidase I, is involved in cadmium-glutathione metabolism.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Apr 2009

Adamis Paula D B, Mannarino Sergio C, Riger Cristiano J, Duarte Giselle, Cruz Ana, Pereira Marcos D, Eleutherio Elis C A

Abstract excerpt

In Saccharomyces cerevisiae, accumulation of cadmium-glutathione complex in cytoplasm inhibits cadmium absorption, glutathione transferase 2 is required for the formation of the complex and the vacuolar gamma-glutamyl transferase participates of the first step of glutathione degradation. Here, we proposed that Lap4, a vacuolar amino peptidase, is involved in glutathione catabolism under cadmium stress....

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Source

Identifiers

PMID: 18716881
DOI: 10.1007/s10534-008-9160-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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