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Article

VNTR alleles associated with the alpha-globin locus are haplotype and population related.

American journal of human genetics - 1 Sept 1994

Martinson J J, Boyce A J, Clegg J B

Abstract excerpt

The human alpha-globin complex contains several polymorphic restriction-enzyme sites (i.e., RFLPs) linked to form haplotypes and is flanked by two hypervariable VNTR loci, the 5' hypervariable region (HVR) and the more highly polymorphic 3'HVR. Using a combination of RFLP analysis and PCR, we have characterized the 5'HVR and 3'HVR alleles associated with the alpha-globin haplotypes of 133 chromosomes, and we here...

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Identifiers

PMID: 7915879
PMCID: PMC1918386

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