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Article

Molecular and population genetic analysis of allelic sequence diversity at the human beta-globin locus.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1994

Fullerton S M, Harding R M, Boyce A J, Clegg J B

Abstract excerpt

Allelic sequence polymorphism at the beta-globin locus was investigated in a group of 36 Melanesians. A 3-kilobase fragment containing the gene and its flanking regions was sequenced in 60 normal (beta A) and 12 thalassemic (intron 1, position 5, G-->C) chromosomes. Haplotype relationships between linked polymorphisms were derived by allele-specific PCR amplification and sequencing. Seventeen nucleotide...

Topics

Alleles
Base Sequence
Biological Evolution
Black People
DNA
Genetic Variation
Genetics, Population
Globins
Haplotypes
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Polymorphism, Restriction Fragment Length

Vanuatu

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Open in PubMed Open full text

Identifiers

PMID: 7907422
DOI: 10.1073/pnas.91.5.1805
PMCID: PMC43252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7907422-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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