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Article

Molecular and population genetic analysis of allelic sequence diversity at the human beta-globin locus.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1994

Fullerton S M, Harding R M, Boyce A J, Clegg J B

Abstract excerpt

Allelic sequence polymorphism at the beta-globin locus was investigated in a group of 36 Melanesians. A 3-kilobase fragment containing the gene and its flanking regions was sequenced in 60 normal (beta A) and 12 thalassemic (intron 1, position 5, G-->C) chromosomes. Haplotype relationships between linked polymorphisms were derived by allele-specific PCR amplification and sequencing. Seventeen nucleotide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 7907422
DOI: 10.1073/pnas.91.5.1805
PMCID: PMC43252

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