Article
[Multiple endocrine neoplasia type 1 (MEN 1). Molecular genetics, morphology and prognosis].
Der Pathologe - 1 Jun 1994
Schröder S, Padberg B, Capella C, Frilling A, Klöppel G, Heitz P U
Abstract excerpt
The syndrome of multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant tumour disease of the neuroendocrine system with manifestations in the parathyroids, pancreas, duodenum and pituitary gland and rarely also in the stomach and thymus. Recently, the MEN 1 gene locus has been mapped to the long arm of chromosome 11. This gene most likely belongs to the tumour suppressor genes, the allelic loss of...
Topics
- Adrenal Glands
- Adult
- Cell Transformation, Neoplastic
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- Female
- Genes, Tumor Suppressor
- Humans
- Male
- Multiple Endocrine Neoplasia
- Mutation