Article
H-ras Oncogene Mutation and Human Papillomavirus Infection in Oral Carcinomas
1 Jul 1994
Abstract excerpt
OBJECTIVE: Previous in vitro studies have demonstrated that transfection of an activated ras gene induces malignant transformation in epithelial cell lines infected with the human papillomavirus (HPV). The results of these studies support the hypothesis that HPV may cooperate with an activated ras gene in epithelial tumor carcinogenesis. To test this hypothesis in head and neck cancers, we screened 35 oral...
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